Santa Ana is a landlocked municipality in the coastal province of Pampanga.
The municipality has a land area of 39.84 square kilometers or 15.38 square miles which constitutes 1.99% of Pampanga's total area. Its population as determined by the 2020 Census was 61,537. This represented 2.52% of the total population of Pampanga province, or 0.50% of the overall population of the Central Luzon region. Based on these figures, the population density is computed at 1,545 inhabitants per square kilometer or 4,001 inhabitants per square mile.